King JC. Physiology of pregnancy and nutrient metabolism. Am J Clin Nutr. 2000;71:1218S–25S.
Chen M, Guan Y, Huang R, Duan J, Zhou J, Chen T, et al. Associations between the maternal exposome and metabolome during pregnancy. Environ Health Perspect. 2022;130:037003.
Nuñez JR, Colby SM, Thomas DG, Tfaily MM, Tolic N, Ulrich EM, et al. Evaluation of in silico multifeature libraries for providing evidence for the presence of small molecules in synthetic blinded samples. J Chem Inf Model. 2019;59:4052–60.
Burton GJ, Fowden AL. The placenta: a multifaceted, transient organ. Philos Trans R Soc Lond B Biol Sci. 2015;370:20140066.
Kolvatzis C, Tsiantas K, Tsakiridis I, Christodoulou P, Cheilari A, Kalogiannidis I, et al. Metabolomic biomarkers in amniotic fluid for early diagnosis of preterm birth and fetal growth restriction. Folia Med. 2024;66:717–20.
Orczyk-Pawilowicz M, Jawien E, Deja S, Hirnle L, Zabek A, Mlynarz P. Metabolomics of human amniotic fluid and maternal plasma during normal pregnancy. PLoS One. 2016;11:e0152740.
Underwood MA, Sherman MP. Nutritional characteristics of amniotic fluid. NeoReviews. 2006;7:e310–e6.
Underwood MA, Gilbert WM, Sherman MP. Amniotic fluid: not just fetal urine anymore. J Perinatol. 2005;25:341–8.
Kolvatzis C, Tsakiridis I, Kalogiannidis IA, Tsakoumaki F, Kyrkou C, Dagklis T, et al. Utilizing amniotic fluid metabolomics to monitor fetal well-being: a narrative review of the literature. Curēus. 2023;15:e36986.
Zhou Y, Zhao R, Lyu Y, Shi H, Ye W, Tan Y, et al. Serum and amniotic fluid metabolic profile changes in response to gestational diabetes mellitus and the association with maternal–fetal outcomes. Nutrients. 2021;13:3644.
Li L-J, Wang X, Chong YS, Chan JKY, Tan KH, Eriksson JG, et al. Exploring preconception signatures of metabolites in mothers with gestational diabetes mellitus using a non-targeted approach. BMC Med. 2023;21:99.
Clinton CM, Bain JR, Muehlbauer MJ, Li Y, Li L, O’Neal SK, et al. Non-targeted urinary metabolomics in pregnancy and associations with fetal growth restriction. Sci Rep. 2020;10:5307.
Jääskeläinen T, Kärkkäinen O, Jokkala J, Litonius K, Heinonen S, Auriola S, et al. A non-targeted LC-MS profiling reveals elevated levels of carnitine precursors and trimethylated compounds in the cord plasma of pre-eclamptic infants. Sci Rep. 2018;8:14616–2.
Luan H, Meng N, Liu P, Fu J, Chen X, Rao W, et al. Non-targeted metabolomics and lipidomics LC–MS data from maternal plasma of 180 healthy pregnant women. GigaScience. 2015;4:16.
Trowbridge J, Abrahamsson D, Bland GD, Jiang T, Wang M, Park J-S, et al. Extending nontargeted discovery of environmental chemical exposures during pregnancy and their association with pregnancy complications-a cross-sectional study. Environ Health Perspect. 2023;131:1–8.
Ji X, Lakuleswaran M, Cowell W, Kahn LG, Sirota M, Abrahamsson D. Insights into the chemical exposome during pregnancy: a non-targeted analysis of preterm and term births. Environ Sci Technol. 2024;58:20883–93.
Abrahamsson D, Wang A, Jiang T, Wang M, Siddharth A, Morello-Frosch R, et al. A comprehensive non-targeted analysis study of the prenatal exposome. Environ Sci Technol. 2021;55:10542–57.
Dusza HM, Manz KE, Pennell KD, Kanda R, Legler J. Identification of known and novel nonpolar endocrine disruptors in human amniotic fluid. Environ Int. 2022;158:106904.
Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43:e47.
Shen X, Wang R, Xiong X, Yin Y, Cai Y, Ma Z, et al. Metabolic reaction network-based recursive metabolite annotation for untargeted metabolomics. Nat Commun. 2019;10:1516.
Schymanski EL, Jeon J, Gulde R, Fenner K, Ruff M, Singer HP, et al. Identifying small molecules via high resolution mass spectrometry: communicating confidence. Environ Sci Technol. 2014;48:2097–98.
Barupal Dinesh K, Fiehn O. Generating the blood exposome database using a comprehensive text mining and database fusion approach. Environ Health Perspect. 2019;127:097008.
Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, et al. Amended safety assessment of dodecylbenzenesulfonate, decylbenzenesulfonate, and tridecylbenzenesulfonate salts as used in cosmetics. Int J Toxicol. 2010;29:288S–305S.
Andersen A. Amended final report of the safety assessment of dibutyl adipate as used in cosmetics. Int J Toxicol. 2006;25:129–34.
U.S. EPA. Health And Environmental Effects Profile for Phthalic Acids (O-, M-, P-). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/X-86/292 (NTIS PB89138838). 1986. Link: https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=PB89138838&starDB=GRAHIST.
Kim H, Choi MS, Ji YS, Kim IS, Kim GB, Bae IY, et al. Pharmacokinetic properties of acetyl tributyl citrate, a pharmaceutical excipient. Pharmaceutics 2018;10:177.
Johnson W Jr. Final report on the safety assessment of acetyl triethyl citrate, acetyl tributyl citrate, acetyl trihexyl citrate, and acetyl trioctyl citrate. Int J Toxicol. 2002;21:1–17.
Lefevre P, Ashby J. Mitogenic activity of quinoline to the rat, mouse, and guinea pig liver: empirical correlations with hepatic carcinogenicity. Environ Mol Mutagen. 1992;20:39–43.
Nagao M, Yahagi T, Seino Y, Sugimura T, Ito N. Mutagenicities of quinoline and its derivatives. Mutat Res. 1977;42:335–42.
Fiume M, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr, Shank RC, et al. Final report on the safety assessment of sodium cetearyl sulfate and related alkyl sulfates as used in cosmetics. Int J Toxicol. 2010;29:115s–32s.
Inada H, Chihara K, Yamashita A, Miyawaki I, Fukuda C, Tateishi Y, et al. Evaluation of ovarian toxicity of mono-(2-ethylhexyl) phthalate (MEHP) using cultured rat ovarian follicles. J Toxicological Sci. 2012;37:483–90.
Gunnarsson D, Leffler P, Ekwurtzel E, Martinsson G, Liu K, Selstam G. Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes. Reproduction. 2008;135:693–703.
Hao C, Cheng X, Xia H, Ma X. The endocrine disruptor mono-(2-ethylhexyl)phthalate promotes adipocyte differentiation and induces obesity in mice. Biosci Rep. 2012;32:619–29.
Calafat AM, Brock JW, Silva MJ, Gray LE, Reidy JA, Barr DB, et al. Urinary and amniotic fluid levels of phthalate monoesters in rats after the oral administration of di(2-ethylhexyl) phthalate and di-n-butyl phthalate. Toxicology. 2006;217:22–30.
Abraham R, Agola A, Shukla A, Sharma R, Lalit Ameta K, Bellare J, et al. Micellar catalysis by dodecylbenzenesulfonic acid in water: Significance of dynamic micelles. J Mol Liq. 2024;401:124591.
Alegría A, Arriba ÁLFD, Morán JR, Cuellar J. Biodiesel production using 4-dodecylbenzenesulfonic acid as catalyst. Appl Catal B Environ. 2014;160:743–56.
Birnie CR, Malamud D, Schnaare RL. Antimicrobial evaluation of N-alkyl betaines and N-alkyl-N, N-dimethylamine oxides with variations in chain length. Antimicrob Agents Chemother. 2000;44:2514–7.
Maher S, Geoghegan C, Brayden DJ. Safety of surfactant excipients in oral drug formulations. Adv Drug Deliv Rev. 2023;202:115086.
Duan C, Fang Y, Sun J, Li Z, Wang Q, Bai J, et al. Effects of fast food packaging plasticizers and their metabolites on steroid hormone synthesis in H295R cells. Sci Total Environ. 2020;726:138500.
Gad SC. Phthalic anhydride. In: Wexler P, editor. Encyclopedia of toxicology, 4th ed. Oxford: Academic Press; 2024, pp. 631–5.
Eales J, Bethel A, Galloway T, Hopkinson P, Morrissey K, Short RE, et al. Human health impacts of exposure to phthalate plasticizers: an overview of reviews. Environ Int. 2022;158:106903.
Li Z-M, Pal VK, Kannan P, Li W, Kannan K. 1,3-Diphenylguanidine, benzothiazole, benzotriazole, and their derivatives in soils collected from northeastern United States. Sci Total Environ. 2023;887:164110.
Li Z-M, Kannan K. Determination of 1,3-diphenylguanidine, 1,3-Di-o-tolylguanidine, and 1,2,3-triphenylguanidine in human urine using liquid chromatography-tandem mass spectrometry. Environ Sci Technol. 2023;57:8883–9.
Mao K, Jin H, Mao W, Guo R, Che X. Presence of 1, 3-diphenylguanidine and its derivatives in human urine and their human exposure. Environ Res. 2024;263:120252.
Tang S, Sun X, Qiao X, Cui W, Yu F, Zeng X, et al. Prenatal exposure to emerging plasticizers and synthetic antioxidants and their potency to cross human placenta. Environ Sci Technol. 2022;56:8507–17.
Subedi B, Sullivan KD, Dhungana B. Phthalate and non-phthalate plasticizers in indoor dust from childcare facilities, salons, and homes across the USA. Environ Pollut. 2017;230:701–8.
Bui TT, Giovanoulis G, Cousins AP, Magnér J, Cousins IT, de Wit CA. Human exposure, hazard and risk of alternative plasticizers to phthalate esters. Sci Total Environ. 2016;541:451–67.
Rasmussen LM, Sen N, Liu X, Craig ZR. Effects of oral exposure to the phthalate substitute acetyl tributyl citrate on female reproduction in mice. J Appl Toxicol. 2017;37:668–75.
Park J, Park C, Gye MC, Lee Y. Assessment of endocrine-disrupting activities of alternative chemicals for bis(2-ethylhexyl)phthalate. Environ Res. 2019;172:10–7.
Zhang W, Jie J, Xu Q, Wei R, Liao X, Zhang D, et al. Characterizing the obesogenic and fatty liver-inducing effects of Acetyl tributyl citrate (ATBC) plasticizer using both in vivo and in vitro models. J Hazard Mater. 2023;445:130548.
Rea WJ, Patel KD. Reversibility of chronic disease and hypersensitivity. Boca Raton, FL: CRC Press; 2018.
Luongo G, Thorsén G, Östman C. Quinolines in clothing textiles—a source of human exposure and wastewater pollution? Anal Bioanal Chem. 2014;406:2747–56.
Matsukami H, Suzuki G, Takigami H. Compositional analysis of commercial oligomeric organophosphorus flame retardants used as alternatives for PBDEs: concentrations and potential environmental emissions of oligomers and impurities. Environ Sci Technol. 2015;49:12913–21.
van der Veen I, de Boer J. Phosphorus flame retardants: properties, production, environmental occurrence, toxicity and analysis. Chemosphere. 2012;88:1119–53.
Liang K, Niu Y, Yin Y, Liu J. Evaluating the blank contamination and recovery of sample pretreatment procedures for analyzing organophosphorus flame retardants in waters. J Environ Sci. 2015;34:57–62.
Lough AK, Garton GA. The lipids of human pancreas with special reference to the presence of fatty acid methyl esters. Lipids. 1968;3:321–23.
Raatz SK, Bibus D, Thomas W, Kris-Etherton P. Total fat intake modifies plasma fatty acid composition in humans. J Nutr. 2001;131:231–4.
Aleryani SL, Cluette-Brown JE, Khan ZA, Hasaba H, Lopez de Heredia L, Laposata M. Fatty acid methyl esters are detectable in the plasma and their presence correlates with liver dysfunction. Clin Chim Acta. 2005;359:141–9.
Hong SI, Kim JY, Cho SY, Park HJ. The effect of gamma irradiation on oleic acid in methyl oleate and food. Food Chem. 2010;121:93–7.
Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, et al. CROT (Carnitine O-Octanoyltransferase) is a novel contributing factor in vascular calcification via promoting fatty acid metabolism and mitochondrial dysfunction. Arterioscler Thromb Vasc Biol. 2021;41:755–68.
Wernig F, Boles E, Oreb M. De novo biosynthesis of 8-hydroxyoctanoic acid via a medium-chain length specific fatty acid synthase and cytochrome P450 in Saccharomyces cerevisiae. Metab Eng Commun. 2020;10:e00111.
Kapoor R, Huang YS. Gamma linolenic acid: an antiinflammatory omega-6 fatty acid. Curr Pharm Biotechnol. 2006;7:531–4.
Verhoeven NM, Schor DS, Roe CR, Wanders RJA, Jakobs C. Phytanic acid α-oxidation in peroxisomal disorders: Studies in cultured human fibroblasts. Biochim Biophys Acta Mol Basis Dis. 1997;1361:281–6.
Wang X, Chen P, Zhao L, Zhu L, Wu F. Transplacental behaviors of organophosphate tri- and diesters based on paired human maternal and cord whole blood: efficiencies and impact factors. Environ Sci Technol. 2021;55:3091–100.
Hollender J, Schymanski EL, Singer HP, Ferguson PL. Nontarget screening with high resolution mass spectrometry in the environment: ready to go? Environ Sci Technol. 2017;51:11505–12.